U.S. CDC is reporting an increase in invasive meningococcal disease in the U.S. in 2024, mainly attributable to Neisseria meningitidis serogroup Y. Most cases involve a single sequence type, ST-1466. Most of the patients are between 30-60 years old, are Black or African American, or are living with HIV. In addition, most cases caused by this strain had a clinical presentation other than meningitis, such as bacteremia and septic arthritis.