The purpose of this U.S. Centers for Disease Control and Prevention (CDC) Health Alert Network (HAN) Health Advisory is to inform healthcare providers that
- Severe manifestations of monkeypox have been observed in the United States in the current outbreak.
- People who are immunocompromised due to HIV or other conditions are at higher risk for severe manifestations of monkeypox than people who are immunocompetent.
- Because people with HIV-associated immunocompromise are at risk for severe manifestations of monkeypox, the HIV status of all sexually active adults and adolescents with suspected or confirmed monkeypox should be determined.
- There are diagnostic and clinical management strategies that may help address severe manifestations of monkeypox.