The Maine Department of Health and Human Services’ Maine Center for Disease Control and Prevention (Maine CDC) continues to recommend all newborns receive a first dose of hepatitis B vaccine within 24 hours of delivery and complete a three-dose series by age 18 months. The Maine CDC’s guidance for hepatitis B vaccination practices is based on the evidence-based recommendations from the American Academy of Pediatrics (AAP), American Medical Association (AMA), and American Academy of Family Physicians (AAFP). Vaccination remains the best defense against hepatitis B.