The purpose of this HAN is to remind medical providers across Maine of recommendations for diagnosing and treating neuro-, ocular and otic syphilis and HIV-syphilis coinfection. It also serves as a reminder to providers about testing for HIV and syphilis during pregnancy, among people who inject drugs (PWID), and among sexually active men who have sex with men (MSM). This HAN includes reminders that neurosyphilis, ocular syphilis, and otic (NOO) syphilis can occur at any stage of syphilis infection but are more common in individuals with HIV infection. HIV and syphilis are reportable conditions in the State of Maine.