The Maine Center for Disease Control and Prevention (Maine CDC) recently received notification of a case of congenital syphilis (CS). This is the first case of CS reported in Maine in 2025. Per American College of Obstetrics and Gynecology (ACOG) guidelines, all pregnant persons should be tested for syphilis at least once during pregnancy, ideally at the first prenatal visit, and tested again during the third trimester and at birth. Adequate and timely treatment of syphilis in pregnant persons is 98% effective in preventing CS.