May 11, 2020

Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19

A pediatric multi-system inflammatory syndrome, recently reported by authorities in the United Kingdom, is also being observed among children and young adults in New York and elsewhere in the United States. Clinical features vary, depending on the affected organ system, but have been noted to include features of Kawasaki disease or features of shock; however, the full spectrum of disease is not yet known. Only severe cases may have been recognized at this time. This inflammatory syndrome may occur days to weeks after acute COVID-19 illness. This syndrome has features which overlap with Kawasaki Disease and Toxic Shock Syndrome. Inflammatory markers may be elevated (CRP, troponin etc.), and fever and abdominal symptoms may be prominent. Rash also may be present. Myocarditis and other cardiovascular changes may be seen. Some patients have developed cardiogenic or vasogenic shock and required intensive care. Patients with this syndrome who have been admitted to pediatric intensive care units have required cardiac and/or respiratory support.

Advisory (PDF)